The study is looking at how effective ALTO-100 (a new medication) is compared to placebo (a non-active medication) in individuals with bipolar who are currently experiencing a major depressive episode.

What will it involve?
- If suitable, individuals will be randomly placed into an ALTO-100 or a placebo group for 6-weeks.
- Participants in the placebo group will have the opportunity to try ALTO-100 after the study for 7 weeks. Those who found ALTO-100 helpful may be able to continue taking it for a further 7 weeks.
- Participants can stay on select mood stabilisers and/or atypical antipsychotic medications whilst taking part in the study.
- The study will involve up to 12 visits to the clinic, which will include interviews, questionnaires, and a set of short computer-based tasks that measure different aspects of thinking, such as memory, attention, and problem-solving.

Who we are looking for?
- Adults aged 18-70.
- Diagnosis of bipolar (BP-I or BP-II) and currently experiencing a major depressive episode.
- History of at least one manic and/or hypomanic episode.
- Taking a stable dose of medication for the treatment of bipolar that has not been changed in the last two weeks.

This study aims to explore day-to-day experiences of awe in the context of bipolar personal recovery. Participants must be over 18 with a diagnosis of bipolar and have had at least one episode but not currently experiencing an episode. 

Participation includes:
- Brief meeting to introduce the study
- Complete diary entries for 30 days plus additional questionnaires following experiences of awe
- Final meeting to debrief and receive a Love2Shop voucher as a thank you

Recruiting adults based in the UK with a diagnosis of bipolar disorder and access to a functional smartphone. Participants will be reimbursed for time and travel expenses.

Study participation includes:
-Attending in-person with the researchers at the Royal Infirmary of Edinburgh.
-Using innovative digital technology to monitor your sleep and physical activity.
-Regular online check-ins with the research team.

Participate in a research study looking at the connection between metabolic changes and clinical outcomes for people with severe mental health conditions. Participants must live in Scotland and be 16-35 years old with either a diagnosis of major depressive disorder, bipolar disorder or schizophrenia or no diagnosis.

We are recruiting people with bipolar disorder to measure a range of outcomes related to light sensitivity. This includes measuring the structure and function of the retina, and two overnight stays to measure the response of participants melatonin to light at night.